Seth Rogen’s filmmaker wife, Lauren Miller Rogen, has opened up about the profound loneliness she experienced after her mother was diagnosed with Alzheimer’s disease at just 55. Miller Rogen was still in her 20s while navigating the devastating diagnosis.

Speaking exclusively to Page Six at a special screening of “Tangles” earlier this week, Miller Rogen described how isolated she felt during that period. “I was in my 20s, and I felt so alone,” she said.

At the time, Miller Rogen believed her situation set her apart from everyone around her. She struggled with the idea that others could not relate to what she and her family were facing.

“I was sure I was the youngest person who had experienced this, and no one could understand,” she told Page Six. Her perspective eventually changed as she connected with a much larger community affected by Alzheimer’s.

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That discovery did not lessen the heartbreak of her mother’s diagnosis, but it showed Miller Rogen that her experience was not hers alone. Other people also understood the difficult reality she was confronting at such a young age.

“I was not alone, and I was not the youngest, and I was unfortunately, but also fortunately, part of a huge community that did understand,” Miller Rogen shared.

In 2012, Miller Rogen and Seth founded Hilarity for Charity, a nonprofit organization devoted to raising awareness about Alzheimer’s disease. The organization also supports families affected by the progressive brain disorder.

Their advocacy has continued through their entertainment work. Miller Rogen and Seth produced “Tangles,” an animated film centered on a woman whose mother is diagnosed with Alzheimer’s.

The project features a prominent voice cast that includes Julia Louis-Dreyfus, Abbi Jacobson, Bryan Cranston and Beanie Feldstein. The screening gave Miller Rogen an opportunity to discuss the personal experience behind her commitment to Alzheimer’s awareness.

Although there is no cure for the disorder, Miller Rogen said that she and her husband have discovered reasons for optimism through their advocacy. Their work with Hilarity for Charity has also introduced them to information about maintaining brain health.

“At Hilarity for Charity, we’ve learned so much about brain health; we have education to teach people how to keep their brains healthy,” she explained.

That education has helped change how Miller Rogen views the broader fight against Alzheimer’s. While she acknowledged that major challenges remain, she said the situation no longer feels as overwhelmingly dark as it once did.

“And so it’s not as dark as it was. There’s still a lot more work to be done, but there is a lot of hope, which is amazing.”

Seth also praised his wife during the conversation. When Page Six suggested that Miller Rogen was the true superstar in their family, he responded by pointing to the many years they have spent together and everything he has witnessed.

“We’ve been together a long time. I’ve seen it all. I’ve seen it firsthand.”

Miller Rogen and Seth, both 44, first met on a blind date in 2004. They married in 2011, one year before founding Hilarity for Charity and turning their attention toward supporting families affected by Alzheimer’s disease.

For Miller Rogen, the community she once believed did not exist became proof that others understood her experience. Through Hilarity for Charity and “Tangles,” the couple has continued raising awareness while holding onto the hope they found through their advocacy.

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