California Governor Gavin Newsom faced tough questions about his COVID-19 pandemic policies during a recent appearance on “The Shawn Ryan Show,” where he was pressed to defend decisions that have drawn criticism from across the political spectrum.

The episode, released Monday, featured a wide-ranging discussion between Newsom and podcast host Shawn Ryan, a former U.S. Navy SEAL. Among the topics discussed were California’s pandemic response, vaccine mandates for children, the impact of lockdowns, and Newsom’s political ambitions.

One of the most direct questions came via Ryan from podcast host Joe Rogan, who has been publicly critical of Newsom’s approach during the pandemic.

“Motherf**ker,” Newsom reacted after learning the question was from Rogan, before adding that he was a fan of the popular podcaster.

Ryan warned that the question would be “tough” and then read it aloud: “Who will be held accountable for mandating COVID-19 vaccines for children, which were unnecessary and ineffective, and who will take responsibility for the unprecedented increases in myocarditis and cancer cases among them?”

Ryan added a second part to the question: “Do you feel any remorse for that draconian decision that was obviously heavily influenced by the pharmaceutical companies’ desire for maximum profit?”

Newsom rejected the suggestion that pharmaceutical companies had influenced his decisions, stating, “I’ve passed some of the most progressive laws against Big Pharma in the nation.”

This Could Be the Most Important Video Gun Owners Watch All Year

Do you think Jimmy Kimmel's apology about his comments about Charlie Kirk was sincere?

By completing the poll, you agree to receive emails from LifeZette, occasional offers from our partners and that you've read and agree to our privacy policy and legal statement.

He went on to defend California’s overall handling of the pandemic and emphasized that the state had worked in coordination with the Trump administration during the crisis.

“I mean, Florida shut down their bars and restaurants before California,” Newsom said.

“The question was, when did we start to unwind some of those restrictions? California was more restrictive and we were certainly aggressive at scale.”

Newsom said that his administration is compiling an “objective review” of its COVID-19 policies and comparing California’s outcomes with those of other states.

Regarding vaccine mandates, Newsom said he relied on the advice of independent medical advisors.

“I took their advice, not as a doctor, but as a governor. So, with humility — seriously — humility and grace, I’ve asked them to have that report done. It’s going to be done next month. And it’ll be the only state that I know of that is putting out a truly objective review of what went right and what went wrong.”

Despite defending the decisions made during the height of the pandemic, Newsom acknowledged that some mistakes were made, specifically mentioning the closure of outdoor spaces.

“I know everyone’s a Goddamn- genius now in hindsight,” he said.

“But at the time, none of us knew what we were up against, including the President of the United States, who I worked very closely with.”

Newsom also said that he worked more closely with President Donald Trump than any other Democratic governor during the pandemic.

“And I say that with the kind of humility he deserves as well — grace that he deserves in terms of the decisions he made early on. We were all up against something none of us had any experience on.”

Toward the end of the interview, Newsom addressed criticisms that California has become a national example of failed pandemic leadership.

“We weren’t the only state doing it, but the state of mind of the ‘California Derangement Syndrome’ — there’s a ‘Trump Derangement Syndrome,’ no question. But there’s also ‘California Derangement Syndrome,’” he said.

“As if California stands unique in some of these interventions and respects. It’s true in some but not all.”

Newsom is widely viewed as a likely contender for the Democratic presidential nomination in 2028.

His public defense of controversial pandemic-era policies is seen as an effort to shore up his record ahead of potential national campaigning.