Anticipation was high and the pressure was intense for Sunday’s second sparring match between Donald Trump and Hillary Clinton.

Twitter was in overdrive, with plenty of outrage over claims from both candidates and plenty of wisecracks on a variety of topics — starting right off the bat when the two frostily didn’t shake hands.

Roseanne Barr and Abraham Lincoln were big stars on Twitter.

Close

As Trump and Hillary met on the campus of Washington University in St. Louis, taking their places on the stage, they didn’t approach each other and #nohandshake quickly began trending.

[lz_third_party includes=https://twitter.com/GMA/status/785285246145093632 align=center width=530]

[lz_third_party includes=https://twitter.com/USATODAYcollege/status/785285254307250176 align=center width=530]

[lz_third_party includes=https://twitter.com/brookbanktv/status/785286723722944512 align=center width=530]

[lz_third_party includes=https://twitter.com/ConservativeFew/status/785292132579962880 align=center width=530]

[lz_third_party includes=https://twitter.com/RealAdamRose/status/785285274053902337 align=center width=530]

Once underway, the contentious debate drew nonstop reaction for the next 90 minutes.

One of the biggest anti-Hillary stars, James Woods, however, tweeted at one point that he was not watching the debate, saying, “The fact that she can get away with such criminal behavior without repercussions makes me ill.”

Who do you think would win the Presidency?

By completing the poll, you agree to receive emails from LifeZette, occasional offers from our partners and that you've read and agree to our privacy policy and legal statement.

But Roseanne Barr was maybe Trump’s biggest cheerleader on Sunday night, praising the Republican presidential candidate for repeatedly for going after Hillary.

[lz_third_party includes=https://twitter.com/therealroseanne/status/785289665938980864 align=center width=530]

[lz_third_party includes=https://twitter.com/therealroseanne/status/785290093133082625 align=center width=530]

[lz_third_party includes=https://twitter.com/therealroseanne/status/785290448638128128 align=center width=530]

[lz_third_party includes=https://twitter.com/therealroseanne/status/785305390082723841 align=center width=530]

Meghan McCain, John McCain’s daughter, also cheered him on.

[lz_third_party includes=https://twitter.com/MeghanMcCain/status/785293424182358016 align=center width=530]

Another trending topic of the night was Abraham Lincoln, who was cited by Hillary, prompting Trump to jump on it, saying there are “big, big differences … between Abraham Lincoln and you.”

[lz_third_party includes=https://twitter.com/maddie_morris21/status/785300651332861952 align=center width=530]

[lz_third_party includes=https://twitter.com/tomdelbeccaro/status/785300515135508480 align=center width=530]

[lz_third_party includes=https://twitter.com/SimonDerienziss/status/785300434135113728 align=center width=530]

[lz_third_party includes=https://twitter.com/PastorDScott/status/785299426633981952 align=center width=530]

[lz_third_party includes=https://twitter.com/billyeichner/status/785296110805889024 align=center width=530]

[lz_third_party includes=https://twitter.com/TheDailyShow/status/785297159532974080 align=center width=530]

And some people just found the whole event exhausting.

[lz_third_party includes=https://twitter.com/AntonioFrench/status/785298518793609216 align=center width=530]

[lz_third_party includes=https://twitter.com/abdulamemon/status/785293824994127872 align=center width=530]