Fueled by a big money onslaught from the U.S. Chamber of Commerce, a Kansas obstetrician toppled a steadfast conservative Republican incumbent congressman Tuesday, sending an unmistakable message: The Establishment is going on offense.

Dr. Roger Marshall scored a lopsided victory over Rep. Tim Huelskamp in the Republican primary, according to incomplete returns. He had 56 percent of the vote, with 99 percent of the precincts reporting. With only minor-party opposition in November, Marshall will be a prohibitive favorite in a largely rural district in western and central Kansas — one of the nation’s most conservative.

A lot of that money went into TV ads depicting Huelskamp — ironically — as the Washington insider. One commercial paid for by EASFund called the congressman “Washing-Tim.”

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Rob Engstrom, political director of the Chamber of Commerce, took a victory lap on Twitter after Tuesday’s outcome became clear: “Governing on the ballot in KS 1. For those who stand & fight for Free Enterprise, you will find no greater friend.”

Huelskamp has been one of the most conservative members of Congress since winning his first election in 2010. He has a 97 percent lifetime voting record in the FreedomWorks scorecard, while Heritage Action gives him a 92 percent voting record for the current session.

But it was not Huelskamp’s voting record that drew fire from Marshall — it was his penchant for rankling the House GOP leadership. Former House Speaker John Boehner kicked him off of the Budget and Agriculture Committees in 2012 as part of a purge against recalcitrant conservatives who had bucked the leadership on key votes, such as budgets and raising the debt ceiling.

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Huelskamp, a member of the conservative House Freedom Caucus, responded by helping to orchestrate Boehner’s ouster from the speakership last year.

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Back home, though, Huelskamp’s absence from the Agriculture Committee sparked discontent in the farming-heavy district. The powerful Kansas Farm Bureau endorsed Marshall, as did ESAFund, a super PAC funded by the billionaire Ricketts family. Meanwhile, the National Rifle Association, Family Research Council, and Club for Growth all supported Huelskamp. He also had the support of Sen. Ted Cruz, even though the firm of the Texas Republican’s campaign manager worked for Marshall.

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The challenger out-raised and outspent Huelskamp. Outside groups poured some $3 million into the race, with the majority of it against the incumbent.

A lot of that money went into TV ads depicting Huelskamp — ironically — as the Washington insider. One commercial paid for by EASFund called the congressman “Washing-Tim.”

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“We find it troubling that Congressman Huelskamp’s determination to stand up for his beliefs and constituents led the former House GOP leadership to punish him by stripping him of his key committee assignments,” the Tea Party Patriots Citizens Fund, a group supporting Huelskamp, said late Tuesday in a statement. “We find it even more troubling that the current House GOP leadership appears not to have lived up to promises it made to Congressman Huelskamp to support his return to those committee assignments.”

After a string of upsets that have knocked off Establishment incumbents in recent years — including then-Majority Leader Eric Cantor — Washington insiders will likely enjoy Tuesday’s result. Huelskamp’s loss — and especially the size of that defeat — could be a major warning sign to conservative House members to be vigilant against an emboldened Establishment coming after them next.