Republican front-runner Donald Trump made it seven in a row Tuesday, knocking Sen. Ted Cruz out of the race with a blowout win in the Indiana primary and putting an end to the #NeverTrump movement.

Meanwhile, although the Democratic primary continues its slog to the inevitable coronation of front-runner Hillary Clinton, Tuesday made it clear that she may continue to suffer embarrassing losses along the way.

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May 3 will be the day that the general election unofficially began.

Here are five takeaways from Tuesday’s results:

1.) Trump is the presumptive nominee. With Cruz dropping out of the race Tuesday, it is now official. In any other year, a front-runner of Trump’s standing likely would have earned the moniker long ago. But commentators have withheld the imprimatur because of the virulence of the anti-Trump sentiment within the GOP and his struggles to command support from a majority of Republican voters.

But with his win in Indiana, he has now broken 50 percent in the last seven contests in a row. Even with a victory in Indiana, Cruz would have faced long odds to win the nomination. On track to win all 57 delegates from Indiana, Trump has a clear path to securing the nomination before the Republican National Convention in Cleveland.

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2.) Cruz ran out of gas. Losing badly in Trump’s home state of New York and in other Northeastern states where he was never expected to do well is one thing. Getting trounced in Indiana is another. The Hoosier State was supposed to be the senator’s last stand. It is demographically friendlier, in a region where Cruz has won or been competitive in other primaries.

Yet, Cruz lost voters from all income levels and all education levels except those with postgraduate degrees, according to exit polls. A silver lining for Cruz is that he won among “very conservative” voters, but he lost badly among somewhat conservative and moderate voters. Trump also bested Cruz among evangelical voters.

3.) The Cruz-Kasich alliance was a failure. Few political moves ever went as badly as the strategic alliance between Cruz and Gov. John Kasich agreeing to coordinate resources. Kasich abandoned Indiana in exchange for Cruz backing off in New Mexico and Oregon. Trump hammered Cruz and Kasich mercilessly, and some voters said the maneuver turned them off.

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Plus, Kasich could not even stick to it consistently. Shortly after the announcement of the deal, he told reporters that Indiana voters should cast ballots for him. And now the race is effectively over before Kasich gets to benefit from the other end of the deal.

4.) Trump has work to do. Despite his victory, exit polls highlighted challenges to Trump in unifying the party. Some 44 percent of primary voters said they would be concerned or scared if Trump were elected president, and a quarter said they would not vote for him in the general election. About a quarter of voters said their vote was mainly against an opponent rather than for a candidate — and Cruz won half of them. In addition, 57 percent of voters said the GOP primary race has served more to divide the party than energize it.

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5.) Hillary can’t shake Bernie. On more favorable turf after several weeks in the Clinton-friendly Northeast, Sanders again shone a spotlight on the front-runner’s vulnerability. He won the white and the male votes by substantial margins. As he has in nearly every state, he demonstrated his Svengali-like appeal to millennials, taking 85 percent of voters from the ages of 17 to 24, and 65 percent of all voters younger than 45. He also won 73 percent of independents.

Sanders managed this performance despite a two-week run in which his losses in five of six primaries made it clear that he could not win the nomination without the intervention of super delegates, saw a steep fundraising drop, and announced that he was laying off workers and re-evaluating his campaign. Yet he still won in Indiana. Not exactly the way Clinton wanted to finish the campaign.

Who would have thought a month ago that the Democratic race would be more likely to result in a contested convention?