Ted Cruz and Marco Rubio have become strange bedfellows in Campaign 2016, at odds in pursuit of the GOP nomination but forced to buddy up to take down an upstart candidate who’s toying in politics as a second job.

But the two pals are parting ways in a most ugly way. While the alliance was always informal and unstated, Cruz has suddenly become viable — and Rubio is suddenly vulnerable. So here they are. Cruz, who handily won his home state of Texas last week, is looking to rip Rubio’s home state of Florida from him through a series of targeted ads leading up to the March 15 primary contest.

A Super PAC tied to Cruz, Keep the Promise I, is planning to make a big play in the Sunshine State. And the PAC’s spokesperson, Kristina Hernandez, said turnabout is fair play, since a Rubio-aligned Super PAC made a strong push to try to take Texas.

“Conservative Solutions spent upwards of $700K in Texas for their candidate, Marco Rubio,” Hernandez told LifeZette in an email. “When we play in Florida, it will be to win.”

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While the two have seemed publicly to be buddies on the trail, at least when it comes to banding together to prevent Trump from securing the nomination, they are now going after one another. But not everyone will say just what’s going on in the fractured friendship.

“Ted Cruz has been cordial and gracious to everyone,” said Kellyanne Conway, the Republican strategist spearheading the Keep the Promise I Super PAC. “He highlights policy differences while refusing to hurl personal insults, and voters are rewarding him. These two gentleman are running for president, and only one will make it.”

But the buddy move can last only so long. Keep the Promise I plans to launch ads hitting Rubio specifically on his involvement with the Gang of Eight, cronyism and sugar subsidies, and his absence on votes in the Senate. The ads were uploaded to the Super PAC’s website on Sunday and the group plans to launch them on the airwaves in Florida soon.

After Super Tuesday and Rubio’s dismal finishes in four contests over the past weekend, Cruz has called for Rubio to bow out of the presidential race if he fails to clinch his home state, saying that if he had lost Texas he would have dropped out.

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Conservative Solutions may have spent a boatload of cash in Texas, but the Florida senator came up with just 3 delegates and 17.7 percent of the vote. Cruz blew past the GOP field with 102 delegates and 43.8 percent of the vote. With two more state wins on Saturday, Cruz is arguably becoming the consensus alternative to front-runner Trump, who currently has 384 delegates to Cruz’s 300 — and Rubio trails both with only 151.

A Monmouth University poll released on Monday shows Trump with 38 percent support, Rubio with 30 percent, and Cruz with 17 percent in the crucial 99-delegate state of Florida. If Cruz were to tighten up the race in Florida and split the vote among anti-Trump voters, it would all but guarantee that Rubio loses in Florida.

That result would likely not do much to rekindle the buddyhood of Cruz and Rubio.