A new push from President Donald Trump and Senate Majority Leader Mitch McConnell to fully repeal Obamacare and then seek a replacement was already imperiled by midday Tuesday, with Sens. Shelly Moore Capito (R-W.V.), Susan Collins (R-Maine), and Lisa Murkowski (R-Alaska) all announcing their opposition — at least to full repeal without a replace in hand.

In their opposition holds or if there are any further GOP defections, it will represent a stunning defeat for the president and Senate GOP leadership.

Trump vented his frustration late Monday and early Tuesday with the Senate GOP, following its failed attempt to rally around a bill that would have partially repealed and replaced Obamacare — before McConnell announced the plan to seek a clean repeal.

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McConnell failed to garner the 50 votes necessary to pass the Better Care Reconciliation Act. Four of the 52 GOP senators defected from their party and pledged to vote against it. While the Democrats crowed in victory, the president unleashed a Twitter tirade.

“Republicans should just REPEAL failing ObamaCare now & work on a new Healthcare Plan that will start from a clean slate. Dems will join in!” Trump tweeted Monday night.

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McConnell signaled that he would follow the president’s advice when he announced Monday night that he would seek a vote on a repeal of Obamacare without ready replacement measures.

“I regret that the effort to repeal and immediately replace the failures of Obamacare will not be successful. That doesn’t mean we should give up,” McConnell added on the Senate floor Tuesday. “In the coming days, the Senate will take up and vote on a repeal of Obamacare combined with a stable, two-year transition period as we work toward patient-centered health care. A majority of the Senate voted to pass the same repeal legislation in 2015. President Obama vetoed it then. President Trump will sign it now.”

On Tuesday morning, Trump renewed his call for an immediate repeal and delayed replace in a series of tweets while also calling out “a few Republicans” for their refusal to cooperate with McConnell.

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“We were let down by all of the Democrats and a few Republicans. Most Republicans were loyal, terrific & worked really hard. We will return!” Trump tweeted. “As I have always said, let ObamaCare fail and then come together and do a great healthcare plan. Stay tuned!”

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“With only a very small majority, the Republicans in the House & Senate need more victories next year since Dems totally obstruct, no votes!” Trump added. “The Senate must go to a 51 vote majority instead of current 60 votes. Even parts of full Repeal need 60. 8 Dems control Senate. Crazy!”

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House Speaker Paul Ryan (R-Wis.) expressed grave concern Tuesday that Obamacare would remain largely intact.

“I’m worried that Obamacare will stand and the law will continue to collapse and people will get hurt in the process,” Ryan admitted Tuesday during a House GOP press conference. “Obamacare is in the middle of a tailspin. This law is collapsing. So we’ve got a promise to keep. And also, we need to step ahead of the problem that this law is collapsing.”

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“That is just the stark reality of the moment,” Ryan added. “So we’re hopeful that the Senate can take the pause that they need to take and move forward on this issue so we can get something done.”

Vice President Mike Pence, though still optimistic, voiced concern over the fate of health care reform as he called upon reluctant moderates in the Senate to do their duty by the American people and relieve them of Obamacare’s stifling burden.

“Since day one of this administration, President Trump has been fighting tirelessly to repeal and replace Obamacare,” Pence said Tuesday at the National Retail Federation’s Annual Retail Advocates Summit. “Every day Obamacare survives is another day the American economy and American families struggle. We all remember the broken promises that made it possible for Obamacare to get passed.”

“While premiums are soaring, choices are plummeting. Next year, nearly 40 percent of America’s counties — including nine entire states — will have only one choice of a health insurance provider, meaning they’ll have essentially no choice at all,” Pence added. “And even worse, dozens of counties will have no health insurance providers whatsoever on the Obamacare exchange in 2018. Men and women behind these statistics are real people facing a real crisis.”

Noting that he and Trump “fully support” McConnell’s decision to “move forward with a bill that just repeals Obamacare and gives Congress time” to agree on replacement measures, Pence said the country must “start with a clean slate.”

“You know, the Senate actually passed the very same bill in 2015 and sent it to President Obama’s desk, and they should do it again,” Pence added.