Leftist Hollywood celebrities are having a tough time with the Senate’s Friday morning cloture vote advancing Brett Kavanaugh’s nomination further along in the path toward the Supreme Court.

Actress Alyssa Milano (“Charmed”), who attended the Kavanaugh hearing a week ago when both the nominee and accuser Christine Blasey Ford testified, had the sharpest reaction to the 51-49 vote on Friday morning, which limits Senate debate to 30 hours — thus clearing the way for a decisive roll call sometime late Saturday.

Milano (shown above left) even targeted President Donald Trump.

“Thank you for voting no on cloture, @LisaMurkowski. Thank you. Thank you. Thank you,” the actress tweeted to Sen. Lisa Murkowski (R-Alaska).

Murkowski voted “no” on moving toward a vote on Kavanaugh’s confirmation.

Milano then followed up her tweet to Murkowski: “The ‘cloture vote’ means the debate around the vote can only be 30 hours and the Dems can’t filibuster.”

(That’s right: Welcome to 2018, where the former star of “Charmed” and “Who’s the Boss?” is explaining the inner workings of the Senate to people on Twitter.)

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Milano also set her sights on President Trump’s reaction to the Kavanaugh news.

“Very proud of the U.S. Senate for voting ‘yes’ to advance the nomination of Judge Brett Kavanaugh,” Trump tweeted.

Milano responded by saying 22 women have accused the president of sexual misconduct.

“Of course you’re proud, @realdonaldtrump. Because if Kavanaugh isn’t held accountable for sexual misconduct, you won’t be either,” the actress tweeted.

She then maturely counted to 22 to represent the women who have thrown allegations at the president.

“Put the pressure on your senators to vote NO on Kavanaugh. He lied under oath, he threatened his opponents during testimony, and he has shown he doesn’t have what it takes to sit on the highest court of law,” Meredith Placko, host of popular web shows such as “Cosplay Coach,” “What the Flick!?” and “Marvel Movie News, wrote on Twitter in reaction to the Kavanaugh news.

“Deadpool 2” and “Catastrophe” actor Rob Delaney responded to the news by reacting to a tweet from Sen. Joe Manchin (D-W.Va.) that encouraged people to watch a recent interview on “Conan” with actress Jennifer Garner.

“Check out my friend Jennifer Garner if you missed her on Conan last night — what a wonderful ambassador for WV!” wrote Manchin.

He included to a link to the interview.

Delaney’s response? “I’ll do that if you vote no on Kavanaugh; how’s that sound?”

The actor then retweeted several anti-Kavanaugh responses, including one from the official Women’s March account that promised to “flood the streets” and “flood the Capitol.”

Academy Award-winning actress Patricia Arquette (“Boyhood,” “True Romance”) retweeted several negative responses, too, including a tweet saying the American Bar Association is reopening its evaluation of Kavanaugh.

Comedian Kathy Griffin (shown above right at the top of this article) did her best to stay relevant by posting a meme that pulled screenshots from the new Lady Gaga movie, “A Star Is Born.”

The tweet was meant to congratulate Sen. Linda Murkowski for her “no” vote on proceeding with the Kavanaugh confirmation vote.

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