Update: Arizona Republican Sen. John McCain, the self-styled “maverick” of the Senate who served three decades in Congress, passed away on Saturday, August 25, 2018, shortly after discontinuing medical treatment for brain cancer.

In his last hours, McCain had turned down further treatment, his family said in a statement.

The Vietnam War veteran, who survived five years as a prisoner of war and went on to become his party’s presidential nominee in 2008, was diagnosed last July with a brain tumor following a procedure earlier in the year to remove a blood clot from above his left eye.

He had not voted since last December.

In a Friday statement, his family revealed how the disease has worsened.

“Last summer, Senator John McCain shared with Americans the news our family already knew: He had been diagnosed with an aggressive glioblastoma, and the prognosis was serious. In the year since, John has surpassed expectations for his survival. But the progress of disease and the inexorable advance of age render their verdict.”

They said, “With his usual strength of will, he has now chosen to discontinue medical treatment.”

Reaction poured in after the family’s announcement.

“John McCain is an American hero, always putting country before self. From Vietnam to the halls of the U.S. Senate, the spirit of service and civility that has guided Sen. McCain’s life stands as a model for all Americans, regardless of political affiliation,” Arizona Gov. Doug Ducey said in a statement.

Senate Majority Leader Mitch McConnell, (R-Ky.), tweeted: “Very sad to hear this morning’s update from the family of our dear friend @SenJohnMcCain. We are so fortunate to call him our friend and colleague. John, Cindy, and the entire McCain family are in our prayers at this incredibly difficult hour.”

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McCain, 81, served in the U.S. Senate for more than two decades and ran for president twice. He lost the GOP nomination to George W. Bush in 2000 and was the Republican nominee in 2008 before losing to Barack Obama in the general election.

The Republican senator from Arizona had been reported to be in stable condition on Friday.

McCain was a prisoner of war in Vietnam for more than five years. Injuries from being tortured left him unable to lift his arms above his head.

Last December, McCain returned to the Senate for the first time since his brain cancer diagnosis. He delivered powerful remarks on the Senate floor addressing the need for bipartisanship amid gridlock in the chamber.

“Make no mistake, my service here is the most important job I have had in my life. And I am so grateful to the people of Arizona for the privilege — for the honor — of serving here and the opportunities it gives me to play a small role in the history of the country I love,” McCain said, acknowledging senators he’s “known and admired.”

“But they knew that however sharp and heartfelt their disputes, however keen their ambitions, they had an obligation to work collaboratively to ensure the Senate discharged its constitutional responsibilities effectively,” he said.

“I want to talk to my fellow Americans a little more, if I may.”

McCain criticized the Senate’s deliberations in the last year, calling them “more partisan, more tribal” than at any time he remembered.

McCain blamed “both sides” for the lack of cooperation.

Earlier this year, McCain penned a memoir titled “The Restless Wave: Good Times, Just Causes, Great Fights, and Other Appreciations,” written by himself and Mark Salter, who had collaborated with McCain on all seven of his other books.

Related: John McCain’s Brain Cancer: What Is Glioblastoma?

“I don’t know how much longer I’ll be here. Maybe I’ll have another five years. Maybe, with the advances in oncology, they’ll find new treatments for my cancer that will extend my life. Maybe I’ll be gone before you read this. My predicament is, well, rather unpredictable,” he wrote. “But I’m prepared for either contingency, or at least I’m getting prepared. I have some things I’d like to take care of first, some work that needs finishing, and some people I need to see. And I want to talk to my fellow Americans a little more, if I may.”

McCain, who had repeatedly been at odds with President Trump and criticized his rhetoric and leadership, said this year that he didn’t want the president to attend his funeral, and preferred that Vice President Mike Pence be there instead.

Last week, Trump signed a $716 billion defense policy bill, titled “John S. McCain National Defense Authorization Act for Fiscal Year 2019,” though he did not mention the senator.

Check out this video for more news about McCain:

This Fox News piece is used by permission; the Associated Press contributed. This article has been updated with the latest news.

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