Mary Tyler Moore, 80, passed away on Wednesday, Jan. 25, Moore’s rep confirmed through a statement to Page Six.

“Today, beloved icon, Mary Tyler Moore, passed away at the age of 80 in the company of friends and her loving husband of over 33 years, Dr. S. Robert Levine,” the statement read.

“A groundbreaking actress, producer, and passionate advocate for the Juvenile Diabetes Research Foundation, Mary will be remembered as a fearless visionary who turned the world on with her smile.”

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It went on to say, “A groundbreaking actress, producer, and passionate advocate for the Juvenile Diabetes Research Foundation, Mary will be remembered as a fearless visionary who turned the world on with her smile.”

Moore had been in a Connecticut hospital for weeks, where her condition had been reported to be “grave.”

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Moore was most famous for “The Mary Tyler Moore Show,” which ran for 168 episodes from 1970 to 1977. Moore played a single career woman working in a newsroom in the series. It was considered a groundbreaking show for women in comedy.

Before her own program, Moore portrayed the wife of Dick Van Dyke on “The Dick Van Dyke Show,” which ran from 1961 to 1966.

Moore won seven Emmy awards, three Golden Globes, and was nominated for an Academy Award for 1981’s “Ordinary People.” Her last role was a guest spot on “Hot in Cleveland” in 2013.

Moore was diagnosed with diabetes at age 33 and had long suffered from health problems. She was a public advocate for the Juvenile Diabetes Research Foundation.

She is survived by her husband, Dr. Robert Levin, whom she married in 1983. Her son, Richie Meeker, previously passed away.